Proteomic Insights into Intrauterine Growth Restriction and Its Role in Asthma Pathogenesis

Abstract

Intrauterine growth restriction (IUGR) increases risk of developing respiratory diseases such as asthma later in life. This study aims to characterize the effects of maternal hypoxia-induced IUGR on the lung proteome and identify key altered pathways relevant to asthma development in male and female adult offspring. Pregnant mice were housed in hypoxic conditions (10.5% oxygen) from gestational day 11 to 17.5 and returned to normoxic conditions until term (gestational day ∼21). Control animals were housed in normoxic conditions throughout pregnancy. Offspring were weighed at birth. At 8 weeks, mice were weighed and right lung tissues collected for analysis. Proteomics profiling was performed..